Editor’s Note: Over 1,000 adolescent girls and young women are infected with HIV every day. This must change, and with your help, it could. The #, launched today, seeks to infuse innovative ideas into existing evidence-informed approaches to better address this urgent and complex issue in 10 hard-hit countries in Eastern and Southern Africa. The Challenge invites innovators to submit Expressions of Interest by March 28 in one of six focus areas. Johnson & Johnson is a proud partner of this challenge. Jaak Peeters, head of Johnson & Johnson’s Global Public Health organization, shares on our Innovation blog why we’re issuing a call for all innovators to step up and share their big ideas on how to face this challenge head-on.