Skip to content

Innovative Medicine
healthcare areas

Search Results

No Results

    Recently Viewed

      Listening...

      Sorry, I don't understand. Please try again

      1. Innovative Medicine /
      2. Neuroscience /
      3. Depression
      Close crop on two eyes

      Depression

      Major depressive disorder (MDD) is one of the most common mental health disorders and a leading cause of disability worldwide, impacting an estimated 280 million people – or about 5 percent of the population. While depression is typically treated with a “one-size-fits-all” approach, no two cases are the same. MDD is a complex, heterogeneous disorder involving multiple regions of the brain and presenting with many distinct symptom combinations. As a result, responses to treatment vary widely.

      With current standard-of-care, more than 70 percent of MDD patients experience residual or persistent symptoms, and about one in three patients are considered to have treatment-resistant depression (TRD), meaning they do not respond to two or more oral antidepressants.

      Major depressive disorder (MDD) impacts an estimated 280 million people.

      J&J’s approach to MDD

      Our approach reflects the complexity of this condition. We’re advancing a pipeline of mechanistically distinct therapies aimed at addressing the biological drivers of MDD, including the residual symptoms that conventional treatments often leave unresolved. We’re committed to exploring new mechanisms of actions to treat MDD, and we are investigating novel adjunctive treatments designed to improve outcomes for patients whose symptoms persist despite treatment with currently available antidepressant treatments.

      Explore

      Learn more about medicines and therapies for depression and other diseases

      More from Johnson & Johnson

      Is this the end of one-size-fits-all treatments for depression?

      For World Mental Health Day, learn how Johnson & Johnson is working to bring personalized psychiatry to the 7 in 10 people with depression whose treatments aren’t getting the job done.

      This researcher made good on his high school promise to improve how we treat depression

      As a teenager, Wayne Drevets, M.D., had friends who struggled with depression—and who ultimately inspired him to focus his career on helping people with the debilitating disorder.

      4 things we now know about treatment-resistant depression

      Imagine being depressed and trying medication after medication—only to find none work. That’s the plight of people with treatment-resistant depression. We look at this little-understood condition, and how researchers are working to crack its code.