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Innovative Medicine

Ibrutinib (IMBRUVICA®) Granted Breakthrough Therapy Designation by U.S. Food and Drug Administration (FDA) for the Development of a Treatment for Chronic Graft-Versus-Host Disease (cGVHD)

- In current clinical practice, there are no FDA-approved treatments for this life-threatening condition - FDA designation suggests potential use of ibrutinib beyond hematologic malignancies - The FDA also granted ibrutinib orphan drug designation for cGVHD

Johnson & Johnson Innovation and Janssen Research & Development Launch World Without Disease QuickFire Challenge

Largest QuickFire competition to date will award up to $500,000 in a research grant and entrance to Johnson & Johnson Innovation, JLABS, to promising transformational healthcare solution Challenge launched at 2016 BIO International Convention during the Bionic Innovation Forum

Janssen Presents New Data Showing INVOKANA® (canagliflozin) is Associated with Greater Blood Glucose Control and Treatment Adherence Compared to DPP-4 Inhibitors

Other Presentations at American Diabetes Association Scientific Sessions® Show INVOKANA® Therapy also is Associated with Achieving Blood Glucose and Blood Pressure Treatment Goals

New Phase 2 Proof-of-Concept Study Shows Canagliflozin Combination Therapy May Support Chronic Weight Management

Combination of Canagliflozin and Phentermine Demonstrates Improvements in Weight Management in Overweight or Obese Patients without T2DM

Daratumumab Significantly Extended Progression-Free Survival in Combination with Lenalidomide and Dexamethasone in Patients with Multiple Myeloma

- Data from Phase 3 MMY3003 (POLLUX) trial to be featured in the Presidential Symposium at the European Hematology Association (EHA) Annual Congress (Abstract LB2238) - Phase 3 MMY3004 (CASTOR) trial data will also be highlighted at EHA - Together, these results show the potential of daratumumab in combination with either a proteasome inhibitor or immunomodulatory agent

Yoshinori Ohsumi, Ph.D., Wins 2016 Dr. Paul Janssen Award for Biomedical Research

As part of an ongoing commitment to support life sciences innovators and the development of integrated, cross-sector solutions to prevent, intercept and cure diseases, Johnson & Johnson today named cell biologist Yoshinori Ohsumi, Ph.D., of the Tokyo Institute of Technology the winner of the 2016 Dr. Paul Janssen Award for Biomedical Research for his pioneering discoveries concerning the molecular basis of autophagy.

Janssen Expands Body of Evidence for INVOKANA® (canagliflozin) with 18 New Data Presentations at American Diabetes Association’s 76th Scientific Sessions®

Comparative Analyses with DPP-4 Inhibitors, Including Sitagliptin, and Findings on Use in Weight Management and Type 1 Diabetes Underscore Janssen Commitment to Improving Diabetes Management