6 Surprising Things You May Not Know About HIV/AIDS Today
COVID-19 Update: Your Latest Questions About Johnson & Johnson's Investigational Vaccine Candidate AnsweredDid you like reading this story? Click the heart to show your love.
The COVID-19 Data Plan: 3 Innovative Ways Johnson & Johnson Is Using Data Science to Fight the PandemicDid you like reading this story? Click the heart to show your love.
A Message from Chairman and CEO Alex Gorsky About Johnson & Johnson's Investigational COVID-19 Vaccine CandidateDid you like reading this message? Click the heart to show your love.
or all the talk of the differences between millennials and preceding generations, there’s one difference that's based in fact: If you were born after 1980, you’ve never known a world without HIV and AIDS.
The HIV virus was first discovered by scientists in 1983, after doctors in Los Angeles and New York began reporting rare types of pneumonia and cancer among gay patients they were treating.
According to the Centers for Disease Control and Prevention (CDC), young people between the ages of 13 and 24 today account for just over one in five HIV diagnoses. Over 80% of these cases occur in gay or bisexual males, and over half of them are African-American.
In fact, “black, gay and bisexual men in the U.S. have a higher HIV rate than any other country in the world,” says, Global Director of Global Community Impact, a division of Johnson & Johnson that aims to help change the trajectory of health for the most vulnerable populations in the world through strategic partnerships.
That's certainly sobering news given the strides we've made with treatment and prevention efforts in the U.S. since the 1980s. Over the past 25 years, Johnson & Johnson alone has developed six HIV medicines and is investigating several promising preventive tools, including an HIV vaccine. The company has also launched programs worldwide to help reduce the burden of HIV in women and children.
“We hope that, with initiatives like these, we can help end HIV/AIDS within a generation,” Fabiano says.
To that end, Johnson & Johnson is sponsoring this year's Global Citizen Festival in New York City, a concert and event in Central Park where young people and world leaders can take action together on a variety of social causes—including the crusade against HIV, especially when it comes to raising awareness among teens and 20-somethings.
In the lead-up to the festival's kickoff, we spoke to top HIV/AIDS experts to find out the six key things the next generation of change agents needs to know to help #makeHIVhistory.
People with HIV today can live long, healthy lives.
An HIV diagnosis was a death sentence 25 years ago. But that’s far from the case today, thanks to cutting-edge antiretroviral treatments that work by keeping patients’ virus loads low, helping their immune systems stay strong.
“Simply getting access to [antiretroviral treatment] has transformed HIV into a chronic illness, allowing people to live near-normal life spans,” says, Global Head, HIV, Global Public Health, Johnson & Johnson.
It's also gotten easier to stick to treatment regimens over the course of a (hopefully long) lifetime.
“Over the years, we’ve developed drugs that are generally well-tolerated and require infrequent dosing, so you shouldn’t have to take more than one pill a day, and sometimes just one or two,” says, Global Marketing Leader, HIV and Respiratory, Janssen Pharmaceutical Companies of Johnson & Johnson.
Coming down the pipeline next: Janssen is currently studying the use of a single-tablet HIV medication that combines just two drugs. An injectable two-drug regimen, given every four weeks, is also in the works.
“Going forward, it may become easier and easier for patients to stay adherent to their prescribed regimens," Trott says, "so they don’t stop taking their medications."
Equally amazing strides have been made on the prevention front.
The holy grail for putting an end to HIV transmission would be a vaccine—a tool Janssen has been studying in the form of a medication that primes the immune system to fight the virus, then boosts it for an extra-potent response.
In a recent Phase 1/2a study, 100% of healthy volunteers exposed to the vaccine developed antibodies to HIV, suggesting they may be shielded from the disease.
“This is really exciting because, while there have been other promising vaccines, none have yet been successful in humans,” Trott says. “And while our results are preliminary, the vaccine was well-tolerated in people, suggesting that we may have a shot at our goal of developing an effective HIV vaccine."
Janssen has also supported the development of a vaginal ring containing an antiretroviral drug—licensed by Janssen to the International Partnership for Microbicides for study that may prove to empower women and girls to protect themselves against HIV.
In fact, two large Phase 3 clinical trials have shown that the ring significantly reduced HIV incidence by more than half among women over the age of 21, and another study found it was tolerated well in girls under the age of 18.
There’s one demographic in the U.S. at particularly high risk of contracting the disease.
This sobering statistic may surprise you: Despite the great strides we’ve made in preventing and treating HIV, over 39,000 people were diagnosed with the disease in the U.S. in 2015, according to the CDC. Almost half of them were black, and 70% were gay and bisexual men.
“Young, black, gay men have a one in two chance of HIV infection over the course of their lifetime,” confirms Phill Wilson, President and Chief Executive Officer of the Black AIDS Institute. “Black people, in general, have a higher risk of HIV infection than any other racial or ethnic group.”
Rates are particularly high in the Deep South, due to a lack of HIV/AIDS education, lack of access to healthcare and stigma around the condition.Share
There are several reasons why this group is so vulnerable.
First, sexual networks tend to be homogeneous; a black, gay man’s sexual network tends to be composed primarily of other black, gay men. "Since there is a higher level of HIV among this group, there is a higher level of risk,” Wilson says. “It’s like playing Russian roulette.”
Rates are particularly high in the Deep South, due to a lack of HIV/AIDS education, lack of access to healthcare and stigma around the condition. Many young black men are unaware they even have the virus, increasing the risk of HIV transmission.
In much of Africa, HIV/AIDS remains a fact of life.
Why the large mortality rate in countries such as South Africa, Kenya, Zambia and Zimbabwe?
“In some of these areas, people still don’t know their HIV status, so they can’t take medications,” explains, Manager of Global Community Impact at Johnson & Johnson.
And even when they are aware, there’s a stigma associated with treatment, so they put it off until they start to show symptoms, Lobben adds. At that point, when their immune systems are greatly weakened, they’re at higher risk of developing such deadly illnesses as tuberculosis.
“Just over half of people around the world with HIV are accessing antiretroviral therapy, but that means another half isn’t,” Bondurant notes.
There is some good news, however: In eastern and southern Africa, treatment coverage more than doubled from 2010 to 2015, increasing from 24% to 54%, according to the World Health Organization.
Johnson & Johnson has helped to contribute to this positive stat by volunteering to make generic versions of its drugs readily available in countries hard-hit by HIV, and by reaching licensing agreements with other companies to produce them at more affordable costs.
Two demographics most at risk outside the U.S. are women and girls.
Women and girls make up more than half of those living with HIV around the world. In fact, young women aged 10-24 are twice as likely to contract HIV as males the same age.
“A large part of this is due to the fact that, especially in lower-income countries, women have virtually no decision-making power when it comes to their sexual and reproductive health,” explains Lobben. Due to social norms, many women find it difficult, if not impossible, to practice safe sex and use condoms.
Johnson & Johnson has vowed to become part of the solution. In 2015, the company became a major partner in the DREAMS (Determined, Resilient, Empowered, AIDS-free, Mentored, Safe women) initiative, a partnership between the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR), the Bill & Melinda Gates Foundation and other groups aimed at reducing HIV infections among teen girls and young women in 10 sub-Saharan African countries.
As part of its commitment, Johnson & Johnson is providing up to $15 million in funding to help empower girls and young women by supporting such services as offering access to HIV testing and condoms.
“The ambitious aim is that we can reduce the incidence of HIV in these communities by 40%,” Bondurant says.
There’s a lot you can do personally to help #makeHIVhistory.
According to the American Psychological Association, 50% of millennials say they want more information about the disease, and 63% say the government needs to spend more on both treatment and prevention of HIV/AIDs.
“We need to really focus on personal awareness and education—what you do not know can kill you,” Wilson says. “It’s 2017, not 1985, but a lot of people are still stuck with old information and not aware of new treatments and preventive tools, as well as how easy and fast it is these days to find out their HIV status.”
You can help spread the word by volunteering or donating to such groups as Greater Than AIDS and the Black AIDS Institute, which both work to reduce stigma of the disease, encourage HIV testing and promote prevention strategies in at-risk communities.
It’s also critical to stay on top of HIV issues politically, not just on the national level, but on the state and city level, as well.
“It’s not just about calling your representatives to ask for more HIV funding," explains Wilson. "It’s also about, for example, knowing why state laws that make it a crime not to disclose your HIV status can cause people to shy away from both testing and treatment."
A simple phone call or letter to your congressperson or senator is one way to get your voice heard—and help support the people who need it most.