Johnson & Johnson Launches INHANCE INTACT™: A Total Shoulder Replacement System Designed for Tissue-Sparing Surgery Providing Day-One Post-Op Mobility

PALM BEACH GARDENS, Fla. – October 13, 2025 – Johnson & Johnson MedTech, a global leader in orthopaedic technologies and solutions, today announced the U.S. launch of INHANCE INTACT™, a proprietary complete instrumentation system specifically developed for subscapularis-sparing total shoulder arthroplasty¹ (TSA), empowering surgeons to replace a damaged shoulder joint while keeping the shoulder muscle intact.

Each year, more than 100,000 Americans undergo TSA² to treat degenerative conditions like osteoarthritis and rotator cuff tears. While effective, the traditional TSA deltopectoral approach often requires detachment of the subscapularis tendon, a key muscle at the front of the shoulder that has been linked to post-operative pain, instability, and tendon failure.^4,5 As a result, patients often face up to six weeks of post-operative immobilization.⁴ The tissue-sparing approach achieved with INHANCE INTACT™ instrumentation allows surgeons to perform shoulder replacement procedures with enhanced joint visualization.¹ Moreover, this approach enables patient shoulder movement as early as day one post-op.^6* This faster rehabilitation supports the shift toward outpatient, minimally invasive care and makes INHANCE INTACT™ ideal for Ambulatory Surgery Centers. By reducing pain and immobilization time, the system helps patients return to work, family and daily routines sooner.^4,5,6

“The introduction of INHANCE INTACT™ marks an important step forward in advancing shoulder care through thoughtful, clinically driven innovation,” said Sharrolyn Josse, Worldwide President, Joint Reconstruction, Johnson & Johnson MedTech. “By offering solutions to surgeons that allow their patients to have immediate mobility, we’re expanding what’s possible for surgeons and strengthening an approach designed to improve outcomes^**, accelerate recovery, and support the shift to outpatient care.”

INHANCE INTACT™ is part of a comprehensive platform designed to meet the evolving demands of TSA procedures.¹ Designed for use with the INHANCE™ Shoulder System, INHANCE INTACT™ integrates a stemless implant⁸, 43 purpose-built instruments¹, and TRUMATCH™ Personalized Solutions to support anatomic precision⁹, bone preservation¹⁰, and surgical accuracy through patient-specific 3D planning.¹¹ Together, the full procedural solution enables surgeons to deliver consistent results across a broad range of care settings.^1,5

“The INHANCE INTACT™ instrumentation allows surgeons to minimize or eliminate post operative subscapularis failure, a potentially devastating complication after anatomic shoulder arthroplasty,” said Dr. Paul J. Favorito, M.D., a board-certified orthopedic surgeon at The Christ Hospital.*** “The simplified approach and precise instrumentation allow anatomic prosthetic reproduction of the glenohumeral joint along with proper soft tissue balancing. This will be my preferred system for all anatomic arthroplasties.”

INHANCE INTACT™ is now commercially available in the U.S. The system will also be showcased at the American Shoulder and Elbow Surgeons (ASES) Annual Meeting, taking place October 15–18, 2025, in San Diego, California. Attendees can visit Booth #401 to explore the platform and learn more from clinical and product experts. Surgeons seeking to learn more or inquire about product availability are encouraged to visit the INHANCE INTACT™ product page.

Orthopaedic Solutions from Johnson & Johnson MedTech
Across Johnson & Johnson, we are tackling the world’s most complex and pervasive health challenges. In Orthopaedics, we are on a mission to keep people moving by leveraging our deep expertise in joint reconstruction, robotics and enabling tech, spine, sports, trauma, and extremities, to develop the next generation of medtech solutions. We offer one of the most comprehensive Orthopaedics portfolios in the world that helps heal and restore movement for the millions of patients we serve. For more, visit our website or follow us on LinkedIn.

About Johnson & Johnson
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for humanity. Learn more about our MedTech sector’s global scale and deep expertise in cardiovascular, orthopaedics, surgery and vision solutions at https://thenext.jnjmedtech.com. Follow us at @JNJMedTech and on LinkedIn. DePuy Synthes Products, Inc. is a Johnson & Johnson company.

Cautions Concerning Forward-Looking Statements
This press release contains “forward-looking statements” as defined in the Private Securities Litigation Reform Act of 1995 regarding the INHANCE INTACT™ System. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or known or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of Johnson & Johnson. Risks and uncertainties include, but are not limited to: uncertainty of commercial success; challenges to patents; competition, including technological advances, new products and patents attained by competitors; manufacturing difficulties and delays; product efficacy or safety concerns resulting in product recalls or regulatory action; changes to applicable laws and regulations, including global health care reforms; changes in behavior and spending patterns of purchasers of health care products and services; and trends toward health care cost containment. A further list and descriptions of these risks, uncertainties and other factors can be found in Johnson & Johnson’s most recent Annual Report on Form 10-K, including in the sections captioned “Cautionary Note Regarding Forward-Looking Statements” and “Item 1A. Risk Factors,” and in Johnson & Johnson’s subsequent Quarterly Reports on Form 10-Q and other filings with the Securities and Exchange Commission. Copies of these filings are available online at www.sec.gov, www.jnj.com or on request from Johnson & Johnson. Johnson & Johnson does not undertake to update any forward-looking statement as a result of new information or future events or developments.

Important Information: Prior to use, refer to the instructions for use supplied with the device(s) or indications, contraindications, warnings and precautions.

© Johnson & Johnson and its affiliates 2025. All rights reserved. US_ORT_JRSH_406408.

Footnotes
*Subscapularis (SSC) insufficiency can result in shoulder instability, which is a prevalent reason for patients requiring follow-up surgery, referred to as revision surgery. Understanding this relationship is crucial, as it can influence recovery and overall shoulder functionality.

** When compared to traditional deltopectoral approach.

*** Dr. Paul J. Favorito, M.D. is a paid consultant for Johnson & Johnson MedTech.

¹ DePuy Synthes. INHANCE INTACT Instruments - Design Rationale. 2025. Windchill 502044549

² DelveInsight. Shoulder Replacement Devices – Market Insights, Competitive Landscape, and Market Forecast – 2030. August 2024. Report No. 5863681.

³ Cecora AJ, Ragland D, Vallurupalli N, Kwon YW, Zuckerman JD, Virk MS. Projections of utilization of primary and revision shoulder arthroplasty in the United States in the next 40 years. J Shoulder Elbow Surg. 2024.

⁴ Lee S, Sardar H, Horner NS, et al. Subscapularis-sparing approaches in shoulder arthroplasty: A systematic review. Journal of Orthopaedics. 2021;24:165-172. doi:https://doi.org/10.1016/j.jor.2021.02.034

⁵ Daher M, Ghoul A, Fares MY, Abboud J, El Hassan B. Subscapular Sparing Approach for Total Shoulder Arthroplasty: A Systematic Review and Meta-Analysis of Comparative Studies. JSES Reviews, Reports, and Techniques. Published online January 2023.

⁶ Lafosse L, Schnaser E, Haag M, Primary total shoulder arthroplasty performed entirely thru the rotator interval: Technique and minimum two-year outcomes. J Shoulder Elbow Surg. 2009; 18; 864-873.

⁷ Desai SS, Nelson RA, Korbel KC, Levine WN, Goldberg SS. Technical note: subscapularis-sparing approach to perform anatomic total shoulder arthroplasty using a multiplanar humeral osteotomy and angled glenoid instruments. Journal of Orthopaedic Surgery and Research. 2022;17(1):14. doi:https://doi.org/10.1186/s13018-021-02900-w

⁸ Johnson & Johnson and its affiliates. INHANCE INTACT Surgical Technique. July 2025. Windchill 502082840

⁹ INHANCE Shoulder System Value Analysis Brief

¹⁰ DePuy Synthes. INHANCE - Glenoid Bone Removal Comparison. 21 Oct 2021. Adaptiv #103840234

¹¹ Trumatch Personalized Solutions Shoulder System Surgical Technique