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    1. Innovative Medicine /
    2. Immunology /
    3. Rheumatology /
    4. Systemic Lupus Erythematosus (SLE)
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    Systemic Lupus Erythematosus (SLE)

    Systemic Lupus Erythematosus (SLE) is a chronic, systemic inflammatory autoimmune disease in which the body’s immune system mistakenly attacks various tissues, causing widespread damage throughout the body with devastating symptoms ranging from severe fatigue, joint pain and swelling, skin rashes, arthritis, photosensitivity (or sensitivity to sunlight), fever, anemia, life-threatening kidney involvement, neurological symptoms and hematologic disorders.

    Tonsil immune cells .webp

    Immunofluorescent imaging of tonsil immune cells from toxicology study evaluating NIK inhibitor for the treatment of Lupus.

    J&J’s approach to SLE

    Challenges remain in the disease management of SLE, and there is a great need to develop new approved treatments with proven safety profiles.

    Building on our legacy of leadership in immunology innovation, we are currently evaluating an immunoselective treatment, designed to potentially address the underlying cause of the disease without impacting other immune functions. This investigational therapy is being studied across multiple auto- and alloantibody-driven diseases, including SLE.

    Explore

    Learn more about medicines and therapies for SLE and other diseases

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