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A health professional prepares the investigational Ebola vaccine
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Latest News

6 Latest Facts About Johnson & Johnson's Ebola Vaccine

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In response to a new Ebola outbreak in Guinea, Johnson & Johnson is providing up to 200,000 doses of its Ebola vaccine regimen to the country for a World Health Organization supported clinical trial. Learn more about the initiative and other top facts about the vaccine regimen for the deadly virus.
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ne of the world's deadliest viral diseases was discovered in 1976 in Zaire, now known as the Democratic Republic of the Congo (DRC), near the Ebola River.

Since then, there have been 31 outbreaks of Ebola Virus Disease (EVD)—the worst of which hit in West Africa in 2014. During that two-year epidemic, more than 11,000 people died in Guinea, Liberia and Sierra Leone. Two in five individuals who were infected with the disease lost their lives.

Johnson & Johnson had already begun working on a potential vaccine for filoviruses—a family of viruses that includes Ebola. In the wake of the 2014 outbreak, the company accelerated those efforts with a focus on Ebola, and continued that work even when the crisis in West Africa had passed.

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A trial participant learns about Ebola and the investigational Ebola vaccine

So when Ebola hit the DRC again in 2018—in what is now known as the second worst outbreak of the disease in history—Johnson & Johnson was prepared to help.

And the company is ready to help once again.

In the wake of the most recent Ebola outbreak, declared in Guinea in February 2021, the World Health Organization (WHO) is launching a new clinical trial in response, and will be deploying the Ebola vaccine regimen developed by the Janssen Pharmaceutical Companies of Johnson & Johnson in collaboration with Bavarian Nordic A/S to frontline and healthcare workers, as well as others at risk of EVD.

In light of this news, we've rounded up the latest facts about Janssen's Ebola vaccine regimen, including lessons learned from its development that could help in the fight against COVID-19.

1.

Research on Janssen's investigational Ebola vaccine regimen began in 2014

Spurred on by the West African Ebola epidemic in 2014, Johnson & Johnson committed to accelerating development and expanding production of a lead two-dose vaccine regimen, combining a Janssen vaccine as the first dose and contracting the second dose of the regimen from Bavarian Nordic A/S.

The company launched multiple clinical trials across the United States, Europe and Africa for the investigational Ebola vaccine regimen in collaboration with global research consortia supported by Europe’s Innovative Medicines Initiative, which is funded through the EU's Horizon 2020 program, as well as other global partners.

It also established partnerships with the U.S. Biomedical Advanced Research and Development Authority (BARDA) to speed the development and manufacture of the vaccine regimen.

2.

The first dose of the Ebola vaccine regimen uses the same technology as Johnson & Johnson's Janssen COVID-19 Vaccine

The Ebola vaccine regimen is comprised of two doses, each containing a different "carrier viral vector." The vector administered in the first dose is based on Janssen’s AdVac® technology; the vector administered in the second dose is based on MVA-BN® technology from Bavarian Nordic.

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Janssen's Ebola vaccine being developed at a plant in Beerse, Belgium

Each technology uses a different type of virus that has been modified so it can safely replicate in humans and safely carry the genetic code for one or more proteins from a second, target virus—in this case, the Ebola virus.

The proteins produced by the genetic code trigger an immune response against the Ebola virus without actually causing the disease itself. And because the carrier viruses are modified, they don't cause illness either.

Janssen's AdVac viral vector platform is the same technology that was used in Johnson & Johnson's Janssen COVID-19 Vaccine as well as in investigational vaccines being researched for HIV, RSV and Zika.

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In April, the World Health Organization granted the vaccine prequalification, which will help facilitate broader access and accelerate registration of Janssen's Ebola vaccine regimen in African countries to help those most in need.

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3.

In response to the Ebola outbreak in the DRC, Johnson & Johnson committed to donating up to 700,000 doses of its vaccine to people at risk in the DRC and the Republic of Rwanda

Ebola emerged again in the DRC in 2018, ultimately leading to more than 3,000 confirmed cases and more than 2,000 deaths.

In the wake of the outbreak, Johnson & Johnson announced in 2019 that it would provide up to 500,000 vaccine regimens for a new clinical study to make the vaccine available to individuals at some risk of Ebola infection who live in areas close to the outbreak zone, with the goal of helping prevent further geographic spread of the disease.

The study was implemented by the DRC's Ministry of Health and National Institute of Biomedical Research and supported by global health organizations, including Médecins Sans Frontières, Epicentre and the London School of Hygiene & Tropical Medicine.

That decision was followed later in the year by a commitment to provide up to 200,000 vaccine regimens to the neighboring Republic of Rwanda to help stop the outbreak from crossing the DRC border.

4.

Approximately 60,000 people have been vaccinated with the first dose of Janssen's Ebola vaccine regimen to date

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The launch of the Umurinzi Ebola vaccination program in Rwanda

The nearly 60,000 people who've begun the preventive Ebola vaccine regimen did so as part of clinical studies and vaccination initiatives.

Data which have been published in prestigious peer-reviewed journals such as JAMA suggest that the vaccine regimen is well tolerated and induces robust and durable immune responses against the same strain of the Ebola virus that was responsible for the West African and DRC outbreaks.

5.

A European authorization is a major milestone

The European Commission granted Marketing Authorization for Janssen's Ebola vaccine regimen in July 2020, making it the first approved vaccine to be developed using Janssen’s vaccine technologies.

“The approval of Janssen’s Ebola vaccine regimen in the EU is a landmark moment for this company," says Paul Stoffels, M.D. Paul Stoffels, M.D.,Vice Chairman of the Executive Committee and Chief Scientific Officer, Johnson & Johnson, Vice Chairman of the Executive Committee and Chief Scientific Officer, Johnson & Johnson. “The approval symbolizes the progress we have made as a company toward achieving our vision of delivering vaccines to communities most at risk of deadly infectious diseases, such as Ebola. Building on our history of redefining treatment paradigms, we are committed to bringing forward vaccines to help overcome the threat of some of the world’s most life-threatening infectious diseases.”

In April, the WHO granted the vaccine prequalification, which will help facilitate broader access and accelerate registration of Janssen's Ebola vaccine regimen in African countries to help those most in need.

6.

May 2021 News Update: A new clinical trial is announced to safeguard healthcare workers and others at risk

On February 14, 2021, health authorities in Guinea officially declared a new Ebola outbreak.

Today, Johnson & Johnson announced it will provide up to 200,000 doses of its Ebola vaccine regimen to support an early access clinical program by the WHO in response to this latest Ebola outbreak in West Africa. The vaccines are part of a stockpile of Ebola vaccine regimens that were created and maintained by the company following the 2014 Ebola outbreak for use in an emergency just like this one.

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Janssen's Ebola vaccine regimen en route to sub-Saharan Africa

Starting today, the WHO program will begin deploying the vaccine regimen to protect frontline workers, healthcare workers and others at increased risk of acquiring EVD in Sierra Leone, with the potential to expand to include other countries in West Africa.

“We are moving with urgency and purpose to help prevent the spread of this latest Ebola outbreak in Guinea,” said Ruxandra Draghia-Akli, M.D., Ph.D. Ruxandra Draghia-Akli, M.D., Ph.D., Global Head, Global Public Health Research & Development, Johnson & Johnson, Global Head, Global Public Health Research & Development, Johnson & Johnson. “We believe that, through the preventive use of Ebola vaccines, the global health community can help protect vulnerable communities living under the threat of this disease.”

*** This story was updated on May 13, 2021

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Johnson & Johnson's Global Public Health team is at the forefront of combating infectious diseases worldwide—like Ebola and HIV.

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